Abstract

Case Study

An Instance of Green-tinted Urine Related to the use of Propofol

Bindhya Maharjan*, Jeevan Singh, Shibesh Chandra Mishra and Saubhagya Neupane

Published: 20 August, 2024 | Volume 8 - Issue 1 | Pages: 001-004

Urine typically has an amber-yellow color due to the amorphous pigment urochrome, a distinct scent, and an average pH of 6.0, which is somewhat acidic. Green urine can result from drug intake, dyes, infections, adverse drug reactions, and other causes. Less than 1% of propofol users experience green urine, a rare and benign side effect. The green tint in urine is caused by the phenolic metabolites of propofol. In this case, a 33-year-old man diagnosed with organophosphorus poisoning and aspiration pneumonia had been given a modest dose of propofol sedation for six hours and began to exhibit green urine. After five hours of halting the propofol infusion, the urine returned to its usual color. Healthcare practitioners should be aware of this unusual but safe side effect of propofol.

Read Full Article HTML DOI: 10.29328/journal.ijcar.1001024 Cite this Article Read Full Article PDF

Keywords:

Green urine; Propofol; Organophosphorus poisoning; Atropine; Case report

References

  1. Shim YS, Gil HW, Yang JO, Lee EY, Kim SH, Hong SY. A case of green urine after ingestion of herbicides. Korean J Intern Med. 2008;23(1):42-44. Available from: https://doi.org/10.3904/kjim.2008.23.1.42
  2. Bowling P, Belliveau RR, Butler TJ. Intravenous medications and green urine. JAMA. 1981;246(3):216. Available from: https://pubmed.ncbi.nlm.nih.gov/7241760/
  3. Bodenham A, Culank LS, Park GR. Propofol infusion and green urine. Lancet. 1987;2(8561):740. Available from: https://doi.org/10.1016/s0140-6736(87)91097-x
  4. Callander CC, Thomas JS, Evans CJ. Propofol and the color green. Anesthesia. 1989;44(1):82. Available from: https://doi.org/10.1111/j.1365-2044.1989.tb11141.x
  5. Gonenavar MM, Shukla S, Sridhar T, Prasad R, Tabali R. An unusual instance of propofol-triggered green urine in anesthesia management: A case report. MGM J Med Sci. 2024;11:165-168. Available from: https://ouci.dntb.gov.ua/en/works/7njmXnm7/
  6. Sigdel S. Propofol induced green urine. J Anesth Clin Res. 2015;6(7):542. Available from: https://www.longdom.org/open-access-pdfs/propofol-induced-green-urine-2155-6148-1000542.pdf
  7. Ananthanarayan C, Fisher JA. Why was the urine green? Can J Anaesth. 1995;42(1):87-88. Available from: https://doi.org/10.1007/bf03010578
  8. Lee JS, Jang HS, Park BJ. Green discoloration of urine after propofol infusion. Korean J Anesthesiol. 2013;65(2):177-179. Available from: https://doi.org/10.4097/kjae.2013.65.2.177
  9. Blakey SA, Hixson-Wallace JA. Clinical significance of rare and benign side effects: propofol and green urine. Pharmacotherapy. 2000;20(9):1120-1122. Available from: https://doi.org/10.1592/phco.20.13.1120.35041
  10. Fulton B, Sorkin EM. Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation. Drugs. 1995;50(4):636-657. Available from: https://doi.org/10.2165/00003495-199550040-00006
  11. Raymond JR, Yarger WE. Abnormal urine color: differential diagnosis. South Med J. 1988;81(7):837-841. Available from: https://doi.org/10.1097/00007611-198807000-00008
  12. Cooper C. What color is that urine specimen? Am J Nurs. 1993;93(8):37. Available from: https://doi.org/10.1097/00000446-199308000-00017
  13. Motsch J, Schmidt H, Bach A, Böttiger BW, Böhrer H. Long-term sedation with propofol and green discoloration of the liver. Eur J Anaesthesiol. 1994;11(6):499-502. Available from: https://pubmed.ncbi.nlm.nih.gov/7851359/
  14. Takizawa E, Takizawa D, Al-Jahdari WS, Miyazaki M, Nakamura K, Yamamoto K, et al. Influence of atropine on the dose requirements of propofol in humans. Drug Metab Pharmacokinet. 2006;21(5):384-388. Available from: https://doi.org/10.2133/dmpk.21.384
  15. Jelia SC, Lal B, Airan D. Biochemical indicators and the Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning: An observational prospective study. J Acute Dis. 2023;12(4):133-139. Available from: http://dx.doi.org/10.4103/2221-6189.385679
  16. Senarathne R, Hettiaratchi U, Athiththan L, Peiris H, Sarathchandra C, Senanayake H, Weerawansa P, Siribaddana S. Selected liver markers in predicting the severity of organophosphate and carbamate poisoning. J Environ Public Health. 2022;2022:7826396. Available from: https://doi.org/10.1155/2022/7826396
  17. Chaudhary SC, Singh K, Sawlani KK, Jain N, Vaish AK, Atam V, Patel ML, Agarwal A. Prognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning. Toxicol Int. 2013;20(3):214-217. Available from: https://doi.org/10.4103/0971-6580.121669
  18. Parkman HP, Trate DM, Knight LC, Brown KL, Maurer AH, Fisher RS. Cholinergic effects on human gastric motility. Gut. 1999;45(3):346-354. Available from: https://doi.org/10.1136/gut.45.3.346
  19. Loh N, Nair P. Propofol infusion syndrome. Contin Educ Anaesth Crit Care Pain. 2013;13(6):200-202. Available from: http://dx.doi.org/10.1093/bjaceaccp/mkt007
  20. Singh A, Anjankar AP. Propofol-related infusion syndrome: A clinical review. Cureus. 2022;14(10):e30383. Available from: https://doi.org/10.7759/cureus.30383

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